Donald P Bottaro Selected Research

GRB2 Adaptor Protein

12/2008	Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist.
8/2008	Grb2 signaling in cell motility and cancer.
7/2007	Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.

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Donald P Bottaro Research Topics

Disease

38	Neoplasms (Cancer) 06/2022 - 08/2002
11	Neoplasm Metastasis (Metastasis) 01/2020 - 07/2007
11	Renal Cell Carcinoma (Grawitz Tumor) 01/2019 - 12/2004
8	Carcinogenesis 06/2022 - 12/2006
8	Carcinoma (Carcinomatosis) 01/2022 - 10/2014
6	Disease Progression 01/2022 - 07/2009
6	Hypoxia (Hypoxemia) 03/2016 - 12/2006
5	Kidney Neoplasms (Kidney Cancer) 09/2012 - 12/2004
4	Stomach Neoplasms (Stomach Cancer) 01/2021 - 01/2013
3	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 07/2009
2	Breast Neoplasms (Breast Cancer) 01/2020 - 07/2014
2	Hepatocellular Carcinoma (Hepatoma) 05/2017 - 01/2012
2	Adenocarcinoma 01/2016 - 01/2013
2	Hypertension (High Blood Pressure) 01/2013 - 01/2013
1	Circulating Neoplastic Cells 01/2021
1	Urogenital Neoplasms 01/2021
1	Sickle Cell Trait 01/2019
1	Hemoglobinopathies 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Triple Negative Breast Neoplasms 01/2018
1	Lung Neoplasms (Lung Cancer) 03/2017
1	Melanoma (Melanoma, Malignant) 03/2017
1	Colonic Neoplasms (Colon Cancer) 03/2017
1	Necrosis 01/2015
1	Retinoblastoma (Glioblastoma, Retinal) 08/2014
1	Fatigue 01/2013

Drug/Important Bio-Agent (IBA)

14	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2006
11	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2018 - 12/2004
10	Proteins (Proteins, Gene)FDA Link 01/2018 - 08/2008
9	Pharmaceutical PreparationsIBA 01/2019 - 01/2006
6	GSK 1363089IBA 01/2021 - 01/2013
5	cabozantinibIBA 01/2022 - 11/2014
5	Phosphotransferases (Kinase)IBA 01/2021 - 02/2009
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2014 - 07/2002
4	Tyrosine Kinase InhibitorsIBA 06/2022 - 01/2015
4	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2017 - 12/2004
4	Proto-Oncogene Proteins c-metIBA 01/2015 - 02/2009
4	beta CateninIBA 04/2009 - 08/2002
3	Indicators and Reagents (Reagents)IBA 01/2018 - 07/2006
3	GRB2 Adaptor ProteinIBA 12/2008 - 07/2007
2	NivolumabIBA 01/2022 - 11/2020
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2021 - 08/2012
2	pazopanib FDA Link 12/2021 - 01/2020
2	ARQ 197IBA 12/2021 - 01/2018
2	Cadherins (E-Cadherin)IBA 01/2020 - 08/2014
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 09/2012
2	LigandsIBA 03/2017 - 10/2008
2	ErbB Receptors (EGF Receptor)IBA 03/2017 - 10/2008
2	5- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- oneIBA 01/2016 - 01/2015
2	Peptides (Polypeptides)IBA 01/2015 - 01/2014
2	UbiquitinIBA 01/2010 - 04/2009
2	Transforming Growth Factor alpha (TGF-alpha)IBA 10/2008 - 07/2002
1	SNX 2112IBA 06/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 06/2022
1	cyclopropapyrroloindoleIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	tyrosine receptor (receptor, tyrosine)IBA 01/2021
1	IpilimumabIBA 11/2020
1	talazoparibIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	PlatinumIBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2020
1	CateninsIBA 01/2020
1	nilotinib FDA Link 01/2020
1	TubulinIBA 01/2020
1	VimentinIBA 01/2020
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2018
1	tepotinibIBA 01/2018
1	EMD1214063IBA 01/2018
1	defactinibIBA 01/2018
1	AntibodiesIBA 01/2018
1	Anaplastic Lymphoma KinaseIBA 03/2017
1	RNA (Ribonucleic Acid)IBA 03/2016
1	DNA (Deoxyribonucleic Acid)IBA 03/2016
1	CrizotinibIBA 01/2016
1	cyanine dye 5IBA 01/2015
1	Cell Surface ReceptorsIBA 10/2014
1	Insulin (Novolin)FDA Link 08/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 08/2014
1	Proto-Oncogene Proteins c-etsIBA 08/2014
1	Phospholipases (Phospholipase)IBA 07/2014
1	DiglyceridesIBA 07/2014
1	Estrogen ReceptorsIBA 07/2014
1	Protein Kinase CIBA 07/2014
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 07/2014
1	Estrogens (Estrogen)FDA Link 07/2014
1	Epidermal Growth Factor (EGF)IBA 07/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2014
1	Mitogen-Activated Protein KinasesIBA 07/2014
1	ParaffinIBA 01/2014
1	Formaldehyde (Formol)FDA Link 01/2014
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2013
1	Early Growth Response Protein 1IBA 01/2012
1	Heparin (Liquaemin)FDA LinkGeneric 01/2012
1	Oxygen (Dioxygen)IBA 04/2011

Therapy/Procedure

17	Therapeutics 01/2022 - 12/2004
1	Immunotherapy 01/2021
1	Drug Therapy (Chemotherapy) 01/2020
1	Aftercare (After-Treatment) 03/2017
1	Prostatectomy (Retropubic Prostatectomy) 01/2016